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- W2364455057 abstract "Objective This research is to investigate the change of serum osteocalcin level and the relationship of serum osteocalcin level to body mass index(BMI),fasting plasma glucose(FPG),fasting plasma insulin(FIns),glycosylated hemoglobin-A_1c(HbA_1c),serum calcium(Ca),serum phosphate(SP) and serum alkaline phosphatase(ALP) level as well as other factors in the subjects with type 2 diabetes mellitus(T2DM).Methods Based on standards of WHO in 1999,47 T2DM patients were selected as T2DM group and 35 healthy subjects as control group.After measured BMI,the fasting blood of T2DM group and control group were collected and the fasting levels of glucose,insulin,HbA_1c,osteocalcin were determined.The relationship of serum osteocalcin level with BMI,FPG,FIns,HbA_1c,Ca,SP and ALP were also analyzed.Osteocalcin level was measured with radioimmunoassay(RIA).The statistical data were analyzed by SPSS 13.0 software.Results The osteocalcin levels of T2DM group decreased significantly than control group [(4.22±0.93) μg/L vs(4.88±0.76) μg/L,P0.01].Serum osteocalcin level was positively correlated with age(r=-0.421,P0.01),FPG(r=-0.414,P0.01),FIns(r=-0.405,P0.01),and HbA_1c(r=-0.283,P0.05),and modestly negatively correlated with BMI,but the difference is not significant.Multiple regression analysis showed that age and HbA_1c were independent related factors in influencing serum osteocalcin levels.Conclusion The fasting serum osteocalcin level decreased in T2DM patients,which may,in part,has a close relation with the hyperglycemia." @default.
- W2364455057 created "2016-06-24" @default.
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- W2364455057 date "2008-01-01" @default.
- W2364455057 modified "2023-09-24" @default.
- W2364455057 title "Change of serum osteocalcin level in type 2 diabetes mellitus patients and its influencing factors" @default.
- W2364455057 hasPublicationYear "2008" @default.
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