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- W2364458410 abstract "Objective: To observe the effects of Kangxian Ruangan granule on the hepatic stellate cell cycle of rat.Methods: SD male rats were gavaged Kangxian Ruangan granule for preparation of a medicament serum.HSC-T6 cell line placed in the incubator at 37℃ under 5% CO2 in culture,were divided into drug group(containing 5 mg / ml,2.5mg / ml,1.25mg / ml three concentration of Kangxian Ruangan granule),drug serum group(plus different concentrations Kangxian Ruangan granule drug serum,5%,10%,20%),blank control group(plus DMEM medium containing 5% FCS) and normal serum(plus normal rat serum).The inhibition of cell proliferation rate was measured by MTT assay and the cell cycle was measured by flow cytometry.Results: The activation of HSC proliferation were inhibited both in the drug group and serum containing,the drug group and the drug-containing serum group were significantly better than the control group(P 0.05,P 0.01).Cells in G0 / G1 phase DNA content in comparison,10% and 20% of the drug-containing serum group were significantly higher than the normal serum group(P 0.05,P 0.01),the drug group were significantly higher than the control group(P 0.05,P 0.01).Conclusion: Kangxian Ruangan granule can block HSC conducted from G1 to S phase(block HSC through the G1 / S checkpoint),resulting in the accumulation of cells in G1 phase block DNA synthesis and replication,play a role in inhibiting the proliferation of HSC." @default.
- W2364458410 created "2016-06-24" @default.
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- W2364458410 date "2013-01-01" @default.
- W2364458410 modified "2023-09-25" @default.
- W2364458410 title "Effects of Kangxian Ruangan granule on hepatic stellate cell cycle of rat" @default.
- W2364458410 hasPublicationYear "2013" @default.
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