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- W2364458624 abstract "Objective To establish stable MiaPaca2 cell lines resistant to 5-Fu and describe the characteristics of this resistant variant. Methods Increase the concentration of 5-Fu, which was exposed to human pancreatic cancer cell line MiaPaca2 gradually to get the 5-Fu resistance cell line named MiaPaca 2-5-Fu. The IC50 and resistance index(RI) of MiaPaca2 and MiaPaca 2-5-Fu cell lines were measured by WST assay. Doubling time was calculated and compared based on the growth curve of these two cell lines, and cell cycles were assayed with flowcytometry method. Results The IC50 increased from (4.29±0.15)μg/mL in MiaPaca2 to (41. 55±2.79)μig/mL in MiaPaca2-5-Fu after 72 h exposure and the RI was 9.68(P = 0.0019). Doubling time of MiaPaca2 and MiaPaca2-5-Fu was (39.52±0.32) h and (43.27±30.33) h respectively (P = 0.0069). The cell cycles of G0/G1 period, S period and G2/M period have a significant difference between these two cell lines(P0.01). Conclusion MiaPaca 2-5-Fu, the 5-Fu resistant phenotype, is a stable and suitable cell model for studying 5-Fu resistant in pancreatic cancer." @default.
- W2364458624 created "2016-06-24" @default.
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- W2364458624 date "2007-01-01" @default.
- W2364458624 modified "2023-09-22" @default.
- W2364458624 title "Establishment and Characterization of 5-Fu-resistant Variant of Human Pancreatic Cancer Cell Line" @default.
- W2364458624 hasPublicationYear "2007" @default.
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