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- W2364458864 abstract "Objective To investigate the effects of blocking renin-angiotensin system on protein kinase C (PKC) activity in diabetic rat kidney. Methods Diabetic model of rats was induced by streptozotocin. Normal rats (group A) were provided as controls. The diabetic rats were divided into four groups: untreated diabetic control rats (group B), diabetic rats treated with Fosilopril (group C), diabetic rats treated with Losartan (group D), and diabetic rats treated with Fosilopril and Losartan (group E). Blood glucose, ratio of kidney weight to body weight (K/B), HbA 1c , urinary protein excretion rate (UPER) and PKC activity in kidney were measured after 24 weeks of treatment. Results (1) K/B and UPER in group B were higher than those in other groups. K/B and UPER in group E were lower than those in group C and D (P0.05), but no significant difference was found between group C and group D; (2) Membrane PKC activity of kidney tissue in group B was higher than that in group A (P0.001), group C, group D and group E (P0.01). Cytosolic PKC activity in group B was lower than that in group A (P0.01), group C, group D and group E (P0.05). Ratio of PKC activities in cytosol fraction to that in membrane fraction in group B was lower than that in group A (P0.001), group C, group D and group E (P0.01). Membrane PKC activitiy in group E was lower than that in group C and D, cytosolic PKC activity and ratio of PKC activities in cytosol fraction to that in membrane fraction in group E were higher than that in group C and D (P0.05), but no significant difference was found between group C and group D. Conclusion (1) Angiotension-converting enzyme inhibitor (ACEI) and angiotension Ⅱ receptor blocker (ARB) can ameliorate renal hypertrophy and UPER in diabetic rats. (2) Long-term hyperglycemia can activate PKC in diabetic kidney and induce translocation of PKC from cytosol to membrane. (3) ACEI and ARB have equivalent inhibitory effects on activation and translocation of PKC in diabetic rat kidney, and combined treatment with ACEI and ARB is better than either of them." @default.
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- W2364458864 date "2003-01-01" @default.
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- W2364458864 title "Effects of blocking renin-angiotensin system on protein kinase C activity in diabetic rat kidney" @default.
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