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- W2364459620 abstract "It is known that both FHC and Bim is involved in the regulation of intracellular iron metabolism,and plays a role in cellular apoptosis caused by ROS.However,the molecular mechanisms of FHC regulating apoptosis are remaining unknown.Using pLexA-Bim L as bait,a pB42AD based cDNA library was screened and FHC was identified as a Bim interacting protein.The interaction domain on Bim was located to BH3 domain.The interaction between FHC and Bim was further verified by co-immunoprecipitation.The subcellular location assay revealed that both Bim and FHC are located to cytoplasm and partially overlap.Over expression of FHC in HEK293 protects the cells from cytotoxity caused by over expressing Bim L.Both over-expression and knock-down analysis of FHC suggest that FHC protects HEK293 cells from hydrogen peroxide treatment.A novel Bim interacting protein,FHC was identified and it was suggested that FHC play a role in Bim mediated apoptosis and oxidative stress." @default.
- W2364459620 created "2016-06-24" @default.
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- W2364459620 date "2011-01-01" @default.
- W2364459620 modified "2023-09-26" @default.
- W2364459620 title "FHC Interacts With Bim and Protects Cell From Apoptosis" @default.
- W2364459620 hasPublicationYear "2011" @default.
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