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- W2364461956 abstract "Objective To explore the relationship of serum cystatin C(CysC) and Adiponectin with macroangiopathy in patients with type 2 diabetes mellitus(T2DM) and hyperuricemia.Methods The patients who were diagnosed as with the following diseases in our Department between 2009 and 2011 were assigned into the corresponding groups:hyperuricemia combined with macroangiopathy(group A,n=60),T2DM combined with macroangiopathy(group B,n=60),and T2DM plus hyperuricemia combined with macroangiopathy(group C,n=60).Another 40 patients without the abovementioned diseases were included as the control group(group D).The levels of serum CysC,Adiponectin,and blood uric acid(BUA) of the subjects were measured and their relationships with macroangiopathy were analyzed.Results The serum CysC levels of group A,group B,and group C were significantly higher than that of group D,and that of group C was higher than that of group A and group B.The serum Adiponectin levels of group A,group B,and group C were significantly lower than that of group D,and that of group C was lower than that of group A and group B.The carotid intima-media thickness(IMT) of group C was higher than that of group A and group B,and that of group B was higher than that of group A(P0.05).Correlation analysis results showed that IMT was negatively correlated with Adiponectin(r=-0.592),and positively correlated with HOMA-IR,BUA,and CysC(r=0.461,0.504,0.685,P0.05).Multiple linear regression analysis showed that CysC,Adiponectin,HOMA-IR,BUA,triacylglycerol(TG),low density lipoprotein cholesterol(LDL-C),body mass index(BMI),systolic blood pressure(SBP),and glycated hemoglobin(HbA1c) were influencing factors.Conclusion Elevated serum CysC level and decreased adiponectin level are associated with hyperuricemia and related with the development of diabetic macroangiopathy." @default.
- W2364461956 created "2016-06-24" @default.
- W2364461956 creator A5082787229 @default.
- W2364461956 date "2013-01-01" @default.
- W2364461956 modified "2023-09-24" @default.
- W2364461956 title "Relationship of Serum Cystatin C and Adiponectin with Macroangiopathy in Patients with Type 2 Diabetes Mellitus and Hyperuricemia" @default.
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