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- W2364462521 abstract "Objective To investigate the in vitro antifungal activity of combination of caspofungin and voriconazole,itraconazole and amphotericin B against clinical strains of Scedosporium apiospermum.Methods Synergy tests were performed using the checkerboard method and following CLSI(Clinical and Laboratory Standards Institute,formerly NCCLS)M382A broth microdilution methods.In vitro interactions were evaluated with fraction inhibitory concentration index(FICI).Results The GM value of voriconazole alone uasage was lower than other antifungal agents in the study significantly.Caspofungin and itraconazole were synergistic for all isolates of S.apiospermum in the study.Caspofungin and amphotericin B showed synergistic for 27% of all S.apiospermum.Indifferent effect was found in combination of caspofungin and voriconazole for all isolates.Conclusion Caspofungin increased antifungal activity of itraconazole in vitro.The combination of caspofungin and itraconazole seems a good choice of antifungal therapy against S.apiospermum infection." @default.
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- W2364462521 date "2010-01-01" @default.
- W2364462521 modified "2023-10-03" @default.
- W2364462521 title "Antifungal activity of combination of caspofungin and voriconazole, itraconazole or amphotericin B against clinical strains of Scedosporium apiospermum in vitro" @default.
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