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- W2364464287 abstract "Objective:To explore the effect of OGG1 gene on the repair Schizandrin B(Sch B) prevent Benzo[a]pyrene(Ba P) induced DNA oxidative stress in HTR8-SVneo cells. Methods:Ba P damage HTR8-SV neo cells for oxidative stress damage model,the cells were divided into blank group,20 μmol/L Ba P group,and Sch B(0.1,0.5,2.0 μmol/L) groups to detect cellular ROS,cellular 8-OHd G,the levels of cellular OGG1 m RNA and OGG1 protein. Results:Compared with blank group, the levels of OGG1 m RNA and OGG1 protein in Ba P group were reduced(P 0.05),but the levels of ROS and 8-OHd G were increased(P0.05). Compared with of Ba P group,the levels of OGG1 m RNA and OGG1 protein were increased in Sch B groups(P0.05),but the levels of ROS and 8-OHd G were reduced(P0.05). Conclusions:Sch B can protect HTR8-SVneo cells DNA from Ba P oxidatie stress injuries. The antioxidant activity may change with OGG1 gene expression levels,which affects the repair of DNA in the cell." @default.
- W2364464287 created "2016-06-24" @default.
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- W2364464287 date "2015-01-01" @default.
- W2364464287 modified "2023-09-23" @default.
- W2364464287 title "Effect of OGG1 Gene on the Repair Schizandrin B Prevent Benzo [a]-pyrene Induced DNA Oxidative Stress in HTR8-SVneo Cells" @default.
- W2364464287 hasPublicationYear "2015" @default.
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