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- W2364464996 abstract "N6-(2-hydroxyethyl)-adenosine(HEA)production by Isaria tenuipes,strain E3,grown on media containing different carbon and nitrogen sources,and supplemented with different amino acids,inorganic salts and chemical precursors,was evaluated.Highest HEA production was recorded on Czapek medium(without sucrose or NaNO3)when starch and(NH4)2HPO4served as carbon and nitrogen sources,respectively Potassium phosphate promoted HEA production when added to Czapek medium containing 3%sucrose and 0.2%(w/v)NaNO3.Supplementation of Czapek medium with adenosine,adenine,arginine,lysine,proline,histidine,tryptophan,L-glutamic acid or serine also increased HEA production.Adenosine and adenine increased HEA yields by~380%,while HEA levels of 2068.21±55.34μg/g were recorded in mycelia harvested from cultures supplemented with arginine(the most effective amino acid for enhancing HEA production by strain E3)compared with 148.56±4.78g in mycelia from unsupplemented controls.Combined mycelium and culture fluid from one liter of arginine-supplemented culture contained up to 13.10±1.48mg/L HEA,representing a 17.2-fold increase over controls." @default.
- W2364464996 created "2016-06-24" @default.
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- W2364464996 date "2013-01-01" @default.
- W2364464996 modified "2023-09-23" @default.
- W2364464996 title "Screening of Culture Medium Constituents and Additives for Producing of N~6-(2-hydroxyethyl)-Adenosine by Isaria tenuipes" @default.
- W2364464996 hasPublicationYear "2013" @default.
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