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- W2364465531 abstract "Objective To prepare and evaluate the physical and chemistry performance of self-made anti-tumor composite coralline hydroxyapatite(CCHA). Methods The coralline hydroxyapatite(CHA) was prepared using hydrothermal exchange reaction.Cisplatin was impregnated into CHA by vacuum freeze-drying techniques.The pores of CHA and CDDP concentration and distribution were analyzed by scanning electron microscopy and spectrum analysis.The leaching liquor of CCHA was collected and measured by high performance liquid chromatography at different intervals during 8 weeks in vivo and in vitro,respectively. Results(1)CDDP was well-distributed in CHA pores in electron microscopy.(2)High performance liquid chromatography(HPLC) showed that the retention times of cisplatin and internal standard were 4.6min and 7.5min,respectively.(3)In the first two weeks of in vitro desorption study,CDDP released rapidly from CDDP-CHA complex.The concentration of CDDP in leaching liquor was extremely high and maintained at the level of(134.54±9.88)μg/mL after 12 weeks.(4) CDDP-CHA complexes produced high CDDP concentration in local regions of implanted SD rats and decreased following time and distance-dependent manners.(5) Serum CDDP concentration remained low(less than 17 μg/mL) in implanted rats,significantly lower than that of local tissue. Conclusion The CCHA has good sustained release function and provides sufficient focal CDDP concentration." @default.
- W2364465531 created "2016-06-24" @default.
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- W2364465531 date "2010-01-01" @default.
- W2364465531 modified "2023-09-25" @default.
- W2364465531 title "Preparation and evaluation of self-made anti-tumor composite coralline hydroxyapatite." @default.
- W2364465531 hasPublicationYear "2010" @default.
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