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- W2364470416 abstract "There are many routes of DNA vaccine immunization, including intramuscularly injection, intradermal injection, subcutaneous injection, gene gun immunization, mucosa immunization, and so on. Different inoculation routes could result in different immunologic potency and persistent time. GAGE gene family are known as the ideally marker and target for diagnosis and therapy of cancer. GAGE-1 gene is a member of this family. In this research, C57BL/6 mice were divided into 4 groups: subcutaneously injected with pcDNA3. 1+/GAGE-1 (experimental group 1), subcutaneously injected with pcD-NA3. 1 +/GAGE-1/ IL-2 (experimental group 2), pcDNA3. 1+ (control group 1), pcDNA3. 1 + / IL-2 (control group 2), which were immunized thrice at week 0,2,4 respectively. 10d after the last boost all mice of each group were subcutaneously inoculated with B16 cells on the left back while with B16- GAGE-1 cells on the right back. The time of visible tumor formation and the size of tumor were recorded and observed. The life span and survival rate of mice after loaded with the tumor cells were analyzed by Log2-Rank statistics and the CTL values." @default.
- W2364470416 created "2016-06-24" @default.
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- W2364470416 date "2009-01-01" @default.
- W2364470416 modified "2023-09-23" @default.
- W2364470416 title "Construction of the GAGE-1 DNA tumor vaccine and its therapeutic efficacy to the tumor" @default.
- W2364470416 hasPublicationYear "2009" @default.
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