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- W2364472734 abstract "Objective To investigate human telomerase reverse transcriptase(hTERT) expression in HCC tissues,provides the basic theory for HCC early detection,treatment choices,prognostic analysis.Methods(1)hTERT gene expression was detected by immunohistochemistry and RT-PCR methods in HCC and the tissues adjacent HCC and normal liver tissue;(2) to compare the positive diagnostics rate of image diagnosis and hTERT detection in HCC and follow up patients.Results(1) There was significant difference of hTERT expression between HCC and paracarcinomatous tissues(P0.01).and no hTERT expression in normal liver tissues.(2) The positive rate of diagnosis in small HCC is higher than what imaging is;and there was significant difference of the positive diagnostics rate between hTERT and imaging(P0.01).(3) During the follow-up period,7 cases of cancer metastasis or recurrence were variable in 18 cases,whom all had hTERT gene expression.Conclusions(1) hTERT in hepatocellular carcinoma tissues has a higher expression levels;(2) hTERT,in diagnosis of HCC :the positive rates of hTERT is higher than that of imaging diagnosis in small HCC;In the diagnosis of tissue adjacent to carcinoma,hTERT is superior to imaging diagnosis.(3) hTERT has heralded the recurrence and metastasis of HCC,which maybe become a valuable marker for diagnosis and prognosis of HCC." @default.
- W2364472734 created "2016-06-24" @default.
- W2364472734 creator A5073740951 @default.
- W2364472734 date "2012-01-01" @default.
- W2364472734 modified "2023-09-26" @default.
- W2364472734 title "Expression and clinical significance of hTERT in hepatocellular carcinoma" @default.
- W2364472734 hasPublicationYear "2012" @default.
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