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- W2364476604 abstract "Objective:To investigate the significance and clinical value of plasma monocyte chemotactic protein-1(MCP-1) in diagnosis of coronary heart disease(CHD) by observation of the concentrations of plasma MCP-1 in patients with CHD.Method:One hundred and twenty-two patients were divided into Non-CHD group(control group,n=30),SAP group(n=32),UAP group(n=27) and AMI group(n=33).In all these groups,the concentrations of plasma MCP-1 and tissue factor(TF) in the patients were detected by ELLSA.Result:①The concentrations of plasma MCP-1 and TF were: control groupSAP groupUAP groupAMI group(all P0.05).②The concentrations of plasma MCP-1 was not correlated with gender,smoking status,history of CHD,hypertension,diabetes,TG,HDL-C,urea nitrogen and creatinine(all P0.05),but it was positively correlated with age,BMI,TC,LDL-C,uric acid,cTnI,CK-MB and TF(all P0.05).③Using concentration of plasma MCP-1 as a diagnostic indicator of acute coronary syndrome,ROC curve analysis showed that MCP-1 had diagnostic value,the area under ROC curve of MCP-1 was 0.939(P0.05),the best critical concentration of plasma MCP-1 was 320.5 ng/L,the specificity and sensitivity were 86.7% and 88.0%.Conclusion:Plasma MCP-1 may have clinical significance in reflecting the vulnerability of atherosclerotic plaque,it may be an independent risk factor of CHD and a good indicator in diagnosis of acute coronary syndrome." @default.
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- W2364476604 date "2012-01-01" @default.
- W2364476604 modified "2023-09-23" @default.
- W2364476604 title "Significance of plasma monocyte chemotactic protein-1 in patients with coronary heart disease" @default.
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