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- W2364478980 abstract "[Objective]To research the effect and optimization drug concentration of Jianpi Jiedu Decoction(JPJDT)in treating experemental HCC transplanted with Bel-7402.[Methods]Ninety male BALB/c athymic mice models were indirect orthotopic transplanted with Bel-7402.After 24 h of postoperation,the 90 athymic mice were distributed randomly into JPJDT groups: A,B,C,D,E,F,G,NS,FT each group had 10 athymic mice.Group A to G were treated by intragastric administration with JPJDT that had been deliquated into 7 kinds of concentration for 8 wk.Group NS were treated by intragastric administration with Sodium Chloride for 8 wk.Group FT were were treated by intragastric administration with FT207(Tegafur) for 8 wk.Live time,change of body weight,tumorigeness,exponent of liver and spleen were observed.Ten male BALB/c athymic mice treated NS were as normal control(DZ).[Results]1.The dissection confirmed that the achievement ratio of making model was 67/88,most tumor of 67suitable patho-samples were multi-nodule.2.Survival state: The live time and survival rate of Group JPJDD were much longer than Group FT(P0.05),the live time in Group D and E was much longer than Group NS(P0.05).3.Body weight state: The body weight of Group JPJDD was increased after treatment(P0.05),while The body weight of Group FT was decrease obviously after treatment(P0.05).4.Dissection state: The index of liver and spleen in Group JPJDD was higher than Group FT(P0.05),the index of spleen in Group C,E,F was higher than Group FT(P0.05),meanwhile The index of spleen of Group C higher than Group D(P0.05).[Conclusion]JPJDD can extend the live time,increase survival rate and increase the body weight of athymic mice with hepatocellular carcinoma.The optimization drug concentration of JPJDT is from 7.5 g/kg to 20.0 g/kg." @default.
- W2364478980 created "2016-06-24" @default.
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- W2364478980 date "2009-01-01" @default.
- W2364478980 modified "2023-09-24" @default.
- W2364478980 title "Anticancer activities of Jianpi Jiedu Decoction on athymic mice with hepatocellular carcinoma" @default.
- W2364478980 hasPublicationYear "2009" @default.
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