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- W2364480254 abstract "Water extract of Clerodendranthus spicatus was successively fractionated using 3 different solvents to provide petroleum ether extract( PE),chloroform extract( CE),ethyl acetate extract( EAE) and water extract( WE). Different antioxidant assays including OH·,O-· 2,DPPH· scavenging activity,reducing power,metal chelating activity,anti-reactive oxygen species( anti-ROS) activity and effects on FeSO4and H2O2induced MDA and GSH-Px production increase were employed to evaluate the antioxidant activities of four extracts. The inhibition rate of mitochondrial swelling induced by Fe2 +-L-Cys in vitro was employed to evaluate the protective effects on mitochondrion. The results showed that all the 4 different extracts had the ability of scavenging DPPH·,O-· 2,·OH and chelating Fe2 +,anti-ROS in vitro,significantly lower the levels of MDA,rised the levels of GSH-Px in renal homogenate and inhibited the renal mitochondria swelling, in concentration dependent manner. The results provided a basis for C. spicatus to be used in the treatment of renal disease." @default.
- W2364480254 created "2016-06-24" @default.
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- W2364480254 date "2014-01-01" @default.
- W2364480254 modified "2023-09-26" @default.
- W2364480254 title "In vitro Antioxidant and Mitochondria Protective Activities of Clerodendranthus spicatus Extracts" @default.
- W2364480254 hasPublicationYear "2014" @default.
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