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- W2364480613 abstract "[Objective]To assess the efficacy and safety of mesalazine versus sulphasalazine in the treatment of ulcerative colitis(UC).[Methods]Such database as PubMed,Cochrane Library,EMbase,CNKI,CBM and Wanfang were searched from their establishment to February 2014 for collecting the randomized controlled trials(RCTs) about Mesalazine versus sulphasalazine for the treatment of UC. After study selection and assessment by the inclusion standard,the meta-analysis was performed by using RevMan5. 2 software,and the quality of studies was evaluated by Jadad evaluation scale.[Results]13 RCTs involving 1 104 patients were included in this study. The results of meta-analysis showed that the total effective rate of the mesalazine group was significantly higher than that of the sulfasalazine group [RR = 1. 21,95% CI(1. 12,1. 32),P 0. 01]. 3 RCTs reported the relapse rate,and the results presented that the relapse rate of the mesalazine group was significantly lower than that of the sulfasalazine group[RR =0.60,95% CI(0.37,0.96),P =0.03]. 9 RCTs reported adverse effects. By the random effect model,the meta-analysis revealed that the incidence of adverse effects in the mesalazine group was significantly lower than that in the sulfasalazine group[RR =0.45,95% CI(0.33,0.59),P 0. 01].[Conclusion]The analysis demonstrates that mesalazine is much more effective and safe than sulfasalazine in the management of UC." @default.
- W2364480613 created "2016-06-24" @default.
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- W2364480613 date "2014-01-01" @default.
- W2364480613 modified "2023-09-23" @default.
- W2364480613 title "Assessment on efficacy and safety of mesalazine versus sulphasalazine in the treatment of ulcerative colitis: a Meta-analysis" @default.
- W2364480613 hasPublicationYear "2014" @default.
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