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- W2364482481 abstract "Objective To investigate the expression of PD-L1 on monocyte derived dendritic cells (MoDCs) and its effect on immune function of HBV-specific T lymphocytes in patients with chronic hepatitis B. Methods The levels of PD-L1 on MoDCs in CHB patients,asymptomatic carrier (ASC) and health controls were detected by fluorescence activated cell sorter (FACS). Before and during telbivudine treatment,MoDCs generated from peripheral blood mononuclear cells (PBMC) were cultured in vitro. The expression of PD-L1 was detected by flow cytometry simultaneously. Followed by mature MoDCs cocultured with xenogenic T cells,in presence or absence of anti-PD-L1 monoclone,MTT assay was applied to determine the proliferation of HBV-specific xenogenic T cells and enzyme-linked immunosorbent assay (ELISA) was applied to test the concentrations of IL-12,IFN-γ and IL-10 in the supernatants of mixed lymphocytes reaction (MLR). Results PD-L1 expression was up-regulated on MoDCs in CHB patients,compared to that of ASC and control groups (P0.05). The level of PD-L1 was positively correlated with serum ALT and HBV DNA. During antiviral treatment,the level of PD-L1 decreased,but with no significant changes (P 0.05). Blocking of PD-L1 signaling with anti-PD-L1 monoclone enhanced the proliferation of MoDCs mediated xenogenic T cells and the levels of IL-12 and IFN-γ,but the level of IL-10 reduced. Conclusions Increasing PD-L1 on MoDCs could decrease the immune function of T cell in patients with-telbivudine treatment on the level of PD-L1 on MoDCs is not significant. Blockage of the PD-L1 pathway may enhance the MoDCs mediating HBV specific T cells immune function." @default.
- W2364482481 created "2016-06-24" @default.
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- W2364482481 date "2012-01-01" @default.
- W2364482481 modified "2023-09-28" @default.
- W2364482481 title "The expression of PD-L1 on monocyte derived dendritic cells and its effect on immune function of T lymphocytes in patients with chronic hepatitis B" @default.
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