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- W2364484217 abstract "Objective:To establish a rat model of hyperandrogenism with pathogenesis similar to PCOS by combined administration of insulin and hCG. Methods:Two month old female SD rats were divided into experimental and control groups. From days 1 to 10, the experimental rats were injected with slowly increasing doses of insulin, from 0.5 IU/d to 6.0 IU/d. Between days 11 and 22, the insulin was injected at a fixed dose of 6.0 IU/d concurrently with hCG (6.0 IU/d) injected twice per day. Rats were sacrificed on day 23. Ovarian histology was examined, and trunk blood was collected for detection of hormone levels. RT-PCR and Western-blot analyses were used to compare the mRNA and protein expression of CYP17 in ovarian cells. Results:Compared with rats from the control group, the rats in the experimental group gained more weight[(53.9±5.6)g, P0.05], the weight of the ovaries increased[(0.13±0.017)g, P0.05], and the ovaries become polycystic. Androstenedione and testosterone levels were increased to [(0.8±0.16)μg/L] and [(4.98±0.5)μmol/L(P0.05)], respectively, and the levels of 17-hydroxyprogesterone and progesterone were also elevated to (10.79±1.78)μg/L and (108.04±24.83)μg/L(P0.05). However, there were no significant differences in dehydroepiandrosterone sulfate levels between the two groups(P0.05). Both the CYP17 mRNA and protein expression in the ovaries of rats from the experimental group were higher than in the control group (P0.05). Conclusions:A rat model that capitulates the features of PCOS and has amplified CYP17 gene function, can be established by combined administration of insulin and hCG. This model may provide a unique advantage for research about hyperandrogenism and PCOS." @default.
- W2364484217 created "2016-06-24" @default.
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- W2364484217 date "2008-01-01" @default.
- W2364484217 modified "2023-09-22" @default.
- W2364484217 title "A Rat Polycystic Ovary Model Established by Combined use of Insulin and Human Chorionic Gonadotrophin" @default.
- W2364484217 hasPublicationYear "2008" @default.
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