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- W2364490061 abstract "AIM Observe the differences of pramipexole mono - therapy and combination application of escitalopram on depressive symptoms and improve life quality of Parkinson' s disease.METHODS Thirty cases of Parkinson' s disease were randomly divided into mono - therapy group and combination therapy group. Pramipexole 0.25 mg,tid or pramipexole 0.25 mg,tid combined with escitalopram 10 mg,qd were treated in two groups respectively,15 cases in each group.Hamilton depression(HAMD) score,Unified Parkinson' s Disease Rating Scale(UPDRS) and the 39-item Parkinson' s Disease Questionnaire(PDQ-39) were observed before the treatment,2 weeks and 8 weeks after the treatment to assessment the change of depress degree and life quality.RESULTS After 2 weeks treatment,HAMD score in combination therapy group was decreased significantly in contrast with the mono-therapy group(P0.05).After 8 weeks treatment,HAMD score, UPDRS score and PDQ - 39 score in both groups were significantly decreased than before the treatment(P0.05),and the combination therapy group were significantly lower than the mono - therapy group(P0.05). CONCLUSION Combined application of escitalopram significantly improve the depressive symptoms and life quality of the patients with Parkinson' s disease in the treatment of early stage,better than pramipexole monotherapy." @default.
- W2364490061 created "2016-06-24" @default.
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- W2364490061 date "2013-01-01" @default.
- W2364490061 modified "2023-09-27" @default.
- W2364490061 title "Comparison of pramipexole monotherapy and combination application of escitalopram to improve depressive symptoms and life quality in Parkinson's disease" @default.
- W2364490061 hasPublicationYear "2013" @default.
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