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- W2364491218 abstract "Objective To study the effect of smoking on airway inflammation of bronchial asthma (asthma) and put forward experimental basis for the treatment of asthma smoking through researching the effect of smoking on the expressional levels of histone deacetylase2 (HDAC2) protein and interleukin-8 (IL-8) in sensitized rats airway and serum. Methods 30 male Wistar rats were divided randomly into control group, sensitized group and smoking sensitized group. The rats of latter two groups were sensitized and challenged by ovalbumin to establish the asthmatic model. From the challenged third weeks, the smoking sensitized group rats were put in the self-made fumigating box to smoke passively. The expressions of HDAC2 protein and IL-8 in airway and serum were defected using immunohistochemistry and ELISA in all rats of three groups. Results ① The expression of HDAC2 protein of smoking sensitized group (0. 339 ±0. 050) were significantly lower than those of the sensitized group (0. 417±0. 044) and the control group (0. 472 ± 0. 047)(all P <0. 05), so did the sensitized group and the control group,( P<0. 05). ②The expression of IL-8 of smoking sensitized group (63. 04±7. 06) ng/L were significantly higher than those of the sensitized group (55. 97 ± 7. 09) ng/L and the control group (47. 25±4. 94) ng/L (all P <0. 05), so did the sensitized group and the control group ( P < 0. 05). ③ The expressions of HDAC2 protein were negatively correlated with the expression of IL-8 ( r = ± 0.59, P < 0. 05). Conclusions Smoking can decrease the expression level of HDAC2 protein in sensitized rats airway and increase the expression level of IL-8 in sensitized rat serum,there existe negative correlation between the expression of histone HDAC2 protein and IL-8, so smoking could aggravate asthma airway inflammation.Key words: Bronchial asthma; Histone deacetylase 2 ; Interleukin-8 ; Smoking" @default.
- W2364491218 created "2016-06-24" @default.
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- W2364491218 date "2011-03-05" @default.
- W2364491218 modified "2023-09-27" @default.
- W2364491218 title "Effect of smoking on expressional levels of histone deacetylase 2 protein and interleukin-8 in sensitized rats airway and serum" @default.
- W2364491218 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2011.005.001" @default.
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