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- W2364492956 abstract "Objective To investigate the changes of venous cord blood nitric oxide(NO) and endotnelin-1(ET-1) levels and to find out its relationship with umbilical arteries blood flow velocities in the pregnant women with diabetes mellitus.Methods 66 cases of the pregnant women with diabetes mellitus(DM) were selected at random,including 30 diabetes mellitus complicated with pregnancies(DMP) and 36 gestational diabetes mellitus(GDM).36 cases of the normal pregnant(NP) women were selected as the control group.Venous cord blood samples were collected from all the subjects after delivery.Cord blood NO and ET-1 levels were detected by Griess assay and radioimmuno-assay respectively,and umbilical arteries blood flow velocities(S/D) were measured just before delivery.Results Compared with the control group,cord blood NO levels decreased and ET-1 levels increased and S/D increased in the DMP group significantly(P0.05).NO level was positive(r=-0.688,P0.05),but ET-1 level was negative(r=0.620,P0.05),related with S/D value in the DMP group.There were no significant differences in NO and ET-1 levels and S/D value between the GDM group and the control group(P0.05).Conclusion Umbilical blood NO and ET-1 levels are abnormal in DMP,which induces the high resistance of fetal-placental circulation,and finally might cause adverse pregnancy outcomes." @default.
- W2364492956 created "2016-06-24" @default.
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- W2364492956 date "2006-01-01" @default.
- W2364492956 modified "2023-09-24" @default.
- W2364492956 title "Nitric oxide and endotnelin-1 concentrations of venous cord blood and its relationship with umbilical arteries blood flow velocity in pregnant women with diabetes mellitus" @default.
- W2364492956 hasPublicationYear "2006" @default.
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