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- W2364493823 abstract "To explore the effects of A20 domain protein on airway remodeling and the expression of NF-κB in asthmatic mice,40 male Balb/c mice were randomly divided into four groups with 10 mice in each group: control group,OVA group,A20 domain protein 3 d group,A20 domain protein 7 d group.The left lung of all groups was isolated and stained with HE and PAS for pathological examination.The concentrations of IL-4,IL-5,TNF-α,and IFN-γ in BALF were measured by ELISA;the RT-PCR and Western blotting were performed to detect the mRNA expression of CTGF/TGF-β1 mRNA and NF-κB in the right lung tissues.In OVA group,all these detected index were higher,including the number of inflammatory cells,the concentrations of IL-4,IL-5,and TNF-α in BALF,the Bronchial airway thickness,the bronchial smooth muscle thickness,the collagen deposition area,as well as the expression of CTGF/TGF-β1 mRNA and NF-κB in lung tissue,but IFN-γ were lower than those in group B(P 0.01).On the contrary,A20 domain protein 3 d group and A20 domain protein 7 d group demonstrated lower level of all these index(P0.05),except IFN-γ which was higher than that in group B(P 0.01).For index mentioned above,there were no significant differences between A20 domain protein 3 d group and A20 domain protein 7 d group(P0.05).All these results indicated that the A20 domain protein can inhibit the development of airway remodeling in asthmatic mice,and the possible mechanism may be due to inhibition of NF-κB/ TGF-β1/CTGF signaling." @default.
- W2364493823 created "2016-06-24" @default.
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- W2364493823 date "2012-01-01" @default.
- W2364493823 modified "2023-09-22" @default.
- W2364493823 title "A20 domain protein inhibits OVA-induced airway remodeling by modulating the NF-κB/TGF-β1/CTGF signaling pathway in asthmatic mice" @default.
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