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- W2364493914 abstract "Objective To study the effects of Gross Saponin of Tribulus Terrestris(GSTT) and Dofetilide on arrhythmias and their mechanisms of antiarrhythmias.Methods Antiarrhythmic effects of GSTT and Dofetilide were observed by arrhythmic models of ligating rat left anterior descending coronary arteries and their antiarrhythmic mechanisms were investigated by isolating cardiac muscle cells in guinea pig and recording delayed outward potassium current(Ikr) and inwardly rectifying potassium current(Ik1) using whole-cell patch clamp technique.Results The number of arrhythmias was decreased significantly by Dofetilide with the dosage of 10 mg·kg~(-1),compared with the controls(P0.01),however GSTT with the dosage of 20 and 40 mg·kg~(-1) did not affect the number of arrhythmias(P0.05).Ikr and Ik1 could not be influenced by 50 and 100 mg·L~(-1) GSTT,but(5 μmol·L~(-1)) Dofetilide could significantly reduce Ikr and Ik1 compared with the controls(P0.01).(Conclusion The) antiarrhythmic mechanisms of Dofetilide are probably related with its inhibiting Ikr and Ik1,GSTT has no effects on arrhythmias because it can not influence Ikr and Ik1." @default.
- W2364493914 created "2016-06-24" @default.
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- W2364493914 date "2005-01-01" @default.
- W2364493914 modified "2023-09-26" @default.
- W2364493914 title "Effects of Gross Saponin of Tribulus Terrestris and Dofetilide on arrhythmic targets" @default.
- W2364493914 hasPublicationYear "2005" @default.
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