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- W2364494300 abstract "Objective To investigate the effect of zinc hydroxide[Zn(OH)2] and low molecular weight hyaluronic acid(LHA) compound adjuvant on humoral immunity induced by hepatitis A and B combined antigen in mice.Methods Zn(OH)2 / LHA compound adjuvant with various formula were added into hepatitis A and B combined antigen respectively.ICR mice were immunized s.c.with the mixture,using aluminium hydroxide adjuvant,physiological saline and adjuvant-free antigen as control.Serum samples were collected 4,8,12 and 16 weeks after immunization and determined for anti-HAV IgG and anti-HBsAg IgG levels by ELISA.Results Except those in physiological saline control group,the serum anti-HAV IgG and anti-HBsAg IgG levels of mice in various groups reached peak values 12 and 8 weeks after immunization respectively then decreased gradually.Most of the anti-HAV IgG and anti-HBsAg IgG levels of mice 4,8,12 and 16 weeks after immunization with hepatitis A and B combined antigen containing Zn(OH)2 / LHA compound adjuvant,at various dosages,increased significantly as compared with those in aluminium hydroxide adjuvant and adjuvant-free antigen control groups(P 0.05),and lasted for a long time.Conclusion The Zn(OH)2 / LHA compound adjuvant with appropriate formula enhanced the humoral immune response induced by hepatitis A and B combined antigen." @default.
- W2364494300 created "2016-06-24" @default.
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- W2364494300 date "2012-01-01" @default.
- W2364494300 modified "2023-09-23" @default.
- W2364494300 title "Enhancement of humoral immunity of hepatitis A and B combined antigen by zinc hydroxide and low molecular weight hyaluronic acid compound adjuvant" @default.
- W2364494300 hasPublicationYear "2012" @default.
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