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- W2364494673 abstract "Objective: To investigate the effect of protein kinase C (PKC) on potassium channel isoform Kv 1.5 of detrusor cell in detrusor instability (DI) rats. Methods: Setting up the model of DI rats, the Kv1.5 mRNA and protein expression of detrusor cultured cell in DI and detrusor stability (DS) rats were detected by RT-PCR and western-blotting techniques, to learn the influence of PMA and H-7 on potassium channel isoform Kv1.5 expression of detrusor cultured cell in DS rats. Results: The Kv1.5 mRNA and protein expressed in DI and DS rats detrusor cultured cell were identified. The Kv1.5 mRNA and protein expression of DI and DS+PMA groups were significantly lower than those of DS group (P0.05～0.01). The Kv1.5 protein expression of DS+PMA group was obviously lower than that of DI group (P0.05) . The Kv1.5 mRNA and protein expression of DS+PMA+H-7 group were significantly higher than those of DI group (P0.05). Conclusions: PKC could obviously inhibit the expression of potassium channel isoform Kv1.5, the changes of pathological mechanism may contribute to DI formation." @default.
- W2364494673 created "2016-06-24" @default.
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- W2364494673 date "2007-01-01" @default.
- W2364494673 modified "2023-09-25" @default.
- W2364494673 title "An experimental study of protein kinase C′s influence on potassium channel of detrusor cell in detrusor instability rats" @default.
- W2364494673 hasPublicationYear "2007" @default.
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