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- W2364496676 abstract "Objective To explore the effect of hyperoxia on the expressions of thioredoxin(Trx) and thioredoxin reductase(TrxR) in embryonic typeⅡalveolar epithelial cells(AECⅡ) of rat.Methods The lung tissue of 19 d fetal rats digested with trypsin and collagenase were isolated and purified in different centrifugal force and different adherences,then the primary fetal rat′s AECⅡwere cultured in vitro.Cells grew to subconfluence and then were randomly divided into air group and hyperoxia group.After standing in culture chamber for 30 min,the air group was put in the same room air,and the hyperoxia group was given 1 000 mL/L oxygen(2 L/min) for 10 min;then culture flasks of the 2 groups were enclosed and cultured in culture chamber.After cells were cultured for 12,24 and 48 h,the effects of hyperoxia on shafe and activity of AECⅡ were observed by inverted phase contrast microscope and the levels of Trx mRNA and TrxR mRNA were detected by semiquantitative reverse transcription polymerase chain reaction.Results Compared with air group,the growth condition of hyperoxia group AECⅡ was not well.After hyperoxia,the levels of Trx mRNA and TrxR mRNA in rat′s embryonic AECⅡ increased remarkably,and peaked at 24 h(t=2.471 P=0.033) and 48 h(t=2.916 P=0.015) respectively.Conclusions The expressions of AECⅡTrx mRNA and TrxR mRNA can be up-regulated by hyperoxia,which might be an important protective mechanism in development of hyperoxia-induced lung injury." @default.
- W2364496676 created "2016-06-24" @default.
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- W2364496676 date "2008-01-01" @default.
- W2364496676 modified "2023-09-24" @default.
- W2364496676 title "Effect of Hyperoxia on Expressions of Thioredoxin and Thioredoxin Reductase in Embryonic Type II Alveolar Epithelial Cells of Rat" @default.
- W2364496676 hasPublicationYear "2008" @default.
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