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- W2364496792 abstract "In this study, we have assessed the effect of gemfibrozil(GF) on apolipoprotein(apo) AI synthesis and secretion and determined the possible mechanism by which apoAI was synthesized by using ELISA, immunoprecipitation and molecular biology techniques including northern blot,mRNA half-life and nuclear run-off. Using highly specific antibodies,we have found that GF increases apoAI secretion and the incorporation of radio-labeled methionine into apoAI by human hepatoma cells line ( HepG2 ). At 200 μM, GF stimulated apoAI secretion by 1585 and de novo synthesis by 30% as compared to control, respectively.Molecular biology data indicated that with varying concentrations of GF, the steady state mRNA level of apoAI was increased up to 204% of control. ApoAI mRNA half-life was prolonged from 14.5 h to 35 h. But nuclear run-off study did not show any change with or without GF. Those data strongly support the concept that the cardioprotective effect of GF may be mediated through hepatic stimulation of apoAI synthesis and secretion. The mechanism is that GF prolongs apoAI mRNA half-life by which to increase mRNA expression in the hepatocytes." @default.
- W2364496792 created "2016-06-24" @default.
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- W2364496792 date "1995-01-01" @default.
- W2364496792 modified "2023-09-28" @default.
- W2364496792 title "The Molecular Biology Mechanism by Which the Drugs Stimulate Human Hepatocytes to Syntheses and Secrete Apolipoprotein AI." @default.
- W2364496792 hasPublicationYear "1995" @default.
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