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- W2364501780 abstract "OBJECTIVE:To establish a method for the determination of sodium valproiate in human serum and to study the bioequivalence of steady state concentration C ssm in of the domestic and imported sodium valproiate sustained-release compound tablets.METHODS:Two periods of multi-oral administration of domestic and imported sodium valproiate sustained-release compound tablets were conducted alternately at random on20healthy male volunteers;the trough concentration of sodium valproate in human serum was determined by HPLC-fluorescence detection and the data were analyzed by3p97proˉgram.RESULTS:The blood concentration was steady after3d oral administration of both the domestic and imported sodium valproate sustained-release compound tablets.The C ssm in of domestic and imported products were(38.17±9.36)、(35.48±9.44)mg/L respectively.C ss min of domestic and imported sodium valproate sustained-release compound tablets were of bioeˉquivalence either single or multi-oral administration.CONCLUSION:This HPLC-fluorescence method is quick,sensitive and economical,which can be used to monitor the concentration of sodium valproate in human serum." @default.
- W2364501780 created "2016-06-24" @default.
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- W2364501780 date "2005-01-01" @default.
- W2364501780 modified "2023-09-25" @default.
- W2364501780 title "Concentration Determination of Sodium Valproate in Human Serum by HPLC-Fluorescence Detection Method" @default.
- W2364501780 hasPublicationYear "2005" @default.
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