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- W2364505978 abstract "Objective To investigate the efficacy of Dezocine on inflammatory factors and postoperative analgesia in old patients undergoing open thoracotomy.Methods Forty patients received lung cancer surgery and cancer of the esophagus under general anesthesia were randomly divided into Dezocine group(group A,n=20) and control group(group B,n=20).TNF-α,IL-6 and IL-10 in plasma in each group were measured immediately before induction of anesthesia(T1),4 h(T2),12 h(T3) and 24 h(T4) after operation.The analgesic effect assessed by visual analog scale(VAS) at T1-4.The MAP,HR and SpO2 were monitored at the same time.The adverse effects were observed with in 24 h after operation.Results TNF-α and IL-6 of the two groups at T2 were significantly increased compare to T1(P0.05),while IL-10 at T3 and T4 were significantly increased compare to T1(P0.05).The TNF-α and IL-6 at T3 and T4 were significantly lower(P0.05),as well as IL-10 were significantly higher at the same time in the group A than in the group B(P0.05).The VAS pain scores in the group A were significantly lower than those in the group B at T3 and T4,respectively(P0.05).The adverse effects after operation of group A were reduced significantly.Conclusion Dezocine has a good postoperative analgesic effect,and can effectively relieve inflammatory reaction without serious adverse effects after operation for old patients un dergoing open thoracotomy." @default.
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- W2364505978 date "2012-01-01" @default.
- W2364505978 modified "2023-09-23" @default.
- W2364505978 title "Effects of Dezocine on inflammatory factors and postoperative analgesia in old patients undergoing open thoracotomy" @default.
- W2364505978 hasPublicationYear "2012" @default.
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