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- W2364506497 abstract "Objective To explore the mechanism of the microglia inflammatory response through observing the changes of interleukin-1 receptor associated kinase-4(IRAK-4) expression in murine N9 microglia cells under hypoxia.Methods N9 cells were exposed to 3%O2,5%CO2,92%N2 for 1,3,6,12 and 24 h respectively.The IRAK-4 protein level was detected by Western blotting and the celluar change was observed by laser scanning confocal microscope(LSCM).The TNF-α level was measured by ELISA.Results After hypoxia,the expression of IRAK-4 protein was increased in a time-dependent manner.The elevation began at 1 h after hypoxia,increased significantly at 3 h(P0.01),peaked at 6 h and remained in higher level at 12 h(P0.01).then decreased at 24 h(P0.05).The fluorescence intensity of IRAK-4 also increased with the extension of anoxic time.The TNF-α level change were similar.There were significant positive correlations between the expression of IRAK-4 and TNF-α(P0.05).Conclusion Hypoxia could increase IRAK-4 expression in murine microglia cells.It suggests that TLR/IL-IR signaling may exist in central nervous system and regulate the subsequent inflammation response." @default.
- W2364506497 created "2016-06-24" @default.
- W2364506497 creator A5053399096 @default.
- W2364506497 date "2008-01-01" @default.
- W2364506497 modified "2023-09-28" @default.
- W2364506497 title "Hypoxia increases IRAK-4 expression in cultured murine N9 microglia cells" @default.
- W2364506497 hasPublicationYear "2008" @default.
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