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- W2364509401 abstract "Objective To observe the therapeutic efficacy and safety of donor leukocyte infusion (DLI) in acute,chronic leukemia and multiple myeloma.Methods Patients included chronic myelogenous leukemia (CML:n=7),acute myelogenous leukemia (AML m 2 :n=2),acute lymphoid leukemia (ALL:n=2) and multiple myeloma (MM:n=2).Leukocyte was apheresised by COBE Spectra,the counts of reinfused leukocyte (CD 3 + cell) were 1.71×1.0 7/kg[ (0.6～3.4)×10 7/kg],and before DLI,discontinued immunosuppressant.Post non myeloablative allogeneic stem cell transplantation (NST) patients usually received DLI one times a month,consecutively 1～4 times.Relapsed patients after varions stem cell transplantation (SCT) or radiochemotherapy,chemotherapy,at the early phase of relapse,also received the same DLI.Results Four post NST CML CP patients formed chimera gradually after two times of DLI,one of four developed aplastic anemia (AA),achieved a complete remission (CR) through treatment.One relapsed post allogeneic bone marrow transplantation (allo BMT) CML CP patient developed severe AA after receiving one time of DLI,recovered and achieved CR 2 through emergency treatment,one CML AP and one CML BP patients,although NST combined with two times of DLI,chimera didn′t form.Two post NST AML m 2a patients,mixed chimera formed after one time of DLI,and they are still in the follow up.Two ALL patients (relapsed patient of post auto PBSCT:n=1,relapsed patient after radiotherapy and chemotherapy:n=1,who received one time of DLI respectively) achieved partial remission (PR) and short CR 2.One of the post NST MM (IgG) type patient,chimera formed and transformed to donor′s type and disease free survival after two times of DLI,another post auto PBSCT relapsed MM (IgA) type patient achieved PR.Only one of thirteen patients developed the first grade chronic graft versus host disease (cGVHD),other side effects were not seen.Conclusion DLI shows better efficacy for post NST CML CP,AML,MM and post allo SCT relapsed CML CP patients,partial efficacy for post NST or post radiotherapy chemotherapy relapsed ALL,MM patients,but no efficacy to post NST CML CP,CML BP patients." @default.
- W2364509401 created "2016-06-24" @default.
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- W2364509401 date "2001-01-01" @default.
- W2364509401 modified "2023-09-23" @default.
- W2364509401 title "Observation on the efficacy of donor leukocyte infusion in acute chronic leukemia and multiple myeloma" @default.
- W2364509401 hasPublicationYear "2001" @default.
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