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- W2364509430 abstract "Objictive To observe antitumor action of heat shock protein-antigen complex (HAC) from glioma. Methods HAC, purified from SD rats C6 cells by immune affinity chromatography, was used to immunize 20 rats as experimental group. 1 week after immunization C6 cells were inoculated into the brain of the rats with stereo orientation method. After 2 weeks the amount of lymphocyte of blood was counted and the concentrations of INF,IL-2 and THF were assayed with ELISA. The survival rate of the rats was observed at the 4th weekend. The brain tissues were obtained from all rats killed at the 4th week for histopathologic and immunohistochemistry examination. Results The amount of peripheral blood lymphocyte and the concentrations of INF, IL-2, THF of the experiment group were significantly higher than those of the controls (P 0.01). The CD3+ and CD4+ T lymphocytes infiltrated in the tumor tissue in the experimental group is significantly more than those in the control group. There was no significant difference of CD8+ T lymphocytes infiltration between the two groups. The ratio of CD4+/CD8+ T lymphocytes of the experiment group is significantly higher than that of the control group (P0.01). Conclusion HAC purified from C6 cells can induce the rats to develop the immune ability against C6 cells, and raise the survival rate of the rats." @default.
- W2364509430 created "2016-06-24" @default.
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- W2364509430 date "2003-01-01" @default.
- W2364509430 modified "2023-09-24" @default.
- W2364509430 title "Antitumor action of heat shock protein-antigen complex from glioma" @default.
- W2364509430 hasPublicationYear "2003" @default.
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