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- W2364510032 abstract "Objective To explore the feasibility of post- autotransplant maintenance therapy in adult acute lymphoblastic leukemia (ALL). Methods The preparative regimen were total body irradiation and cyclophosphamide with or without other chemotherapeutic agents for 38 adult patients receiving autografts in first remission. In an attempt to reduce relapse rate, 19 patients received vincristine- prednisone (VP) and 6- mercaptopurine- methotrexate (MM) and 13 intermittently received interleukin- 2 (IL- 2) after transplant. Among them, 8 patients received VP / MM and IL- 2. Results After a median 990.5 days (range, 18 ～ 4 914 ) of follow- up, eleven patients had a relapse at 79 to 1008 days (median, 212 days), 8 in first year. The cumulative incidence of relapse at 3 years was 43.8 % (95 %CI, 35.1 % ~ 52.5 %). Five died due to transplant- related causes at 18 to 120 days (median, 42 days), 2 in 24 received post- transplant therapy. The probability of disease- free survival (DFS) was 55.7 % (95 %CI, 47.3 % ~ 64.1 %) at 3- year and 5- year. Conclusions Our data suggest that standard ALL- type maintenance chemotherapy and IL- 2 can be administered safely after autotransplantation and improve the outcome of adult ALL patients with undergoing autografting by reducing relapse." @default.
- W2364510032 created "2016-06-24" @default.
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- W2364510032 date "2005-01-01" @default.
- W2364510032 modified "2023-09-25" @default.
- W2364510032 title "Maintenance therapy after autologous hematopoietic stem cell transplantation for adult acute lymphoblastic leukemia" @default.
- W2364510032 hasPublicationYear "2005" @default.
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