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- W2364516300 abstract "Aim To investigate the effect of astragalus injection on the expression of JNK3(c-Jun N terminal kinase 3) protein and JNK3 mRNA in hippocampus of cerebral ischemia reperfusion rats.Methods The rat model of cerebral ischemia reperfusion was built up by the method of four-vessel occlusion.The rats were randomly divided into 4 groups: sham operation group,model group,astragalus injection group and original astragalus injection group.Except sham operation group,the other groups after transient global cerebral ischemia(30 min),were then subdivided into 7 subsets,according to reperfusion times of 0 h,0.5 h,2 h,6 h,24 h,72 h and 120 h.The astragalus injection group was intraperitoneally injected with astragalus(12 g·kg-1) 30 min before ischemia,and the 24 h,72 h,120 h groups were given repeated administration once every 24 h after surgery.The original astragalus injection group was intraperitoneally injected with same dose of distilled water with the astragalus injection.Method of HE staining was used to observe morphological changes in hippocampus CA1 zone.Immunohistochemistry and Western blot were used to measure the expression of JNK3 protein and RT-PCR was used to measure the expression of JNK3 mRNA.Results HE staining showed that astragalus injection significantly improved pathological changes of neurons in hippocampus CA1 zone of rats.Compared with the sham operation group,the expression of JNK3 protein and mRNA in hippocampus very time points increased obviously in model group except 120 h(P0.05).Compared with model group,the expression of JNK3 protein and mRNA in hippocampus very time points decreased obviously in astragalus injection group except 120 h(P0.05),but there was no obvious change in original astragalus injection group(P0.05).Conclusion Astragalus injection can inhibit the expression of JNK3 mRNA in hippocampus of cerebral ischemia and reperfusion rats,moreover,it can inhibit the expression of JNK3 protein,accordingly it inhibits hippocampal neuronal apoptosis induced by cerebral ischemia and reperfusion." @default.
- W2364516300 created "2016-06-24" @default.
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- W2364516300 date "2012-01-01" @default.
- W2364516300 modified "2023-09-28" @default.
- W2364516300 title "Effect of astragalus injection on expression of JNK3 in hippocampus of cerebral ischemia reperfusion rats" @default.
- W2364516300 hasPublicationYear "2012" @default.
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