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- W2364517033 abstract "Objective To study the anti-shock mechanism of polydatin (PD) by measuring the production of nitric oxide (NO) in pulmonary endothelial cells (PECs) stimulated by PD in normal oxygen supply and hypoxic situation. Methods Concentrations of NO production,which were stimulated with PECs in different concentrations and duration,were measured using ultraviolet spectrophotometer. The production of NO expression stimulated by 0.4mmol/L PD in hypoxic PECs was also measured. Results PD significantly stimulated NO production in PECs in a concentration-dependent and time-dependent manners. NO production in highest PD concentration simulated PECs was significantly higher than that in control PECs (maximum of (30.86±2.83)μmol/L ,P0.01). Meanwhile,NO expression significantly increased at 24 h comparing with baseline (maximum of (9.69±4.51) μmol/L,P0.01). Moreover,PD reversed the NO production suppression in hypoxic PECs. Conclusion Polydatin probably up-regulates the NO production in PECs confronting shock." @default.
- W2364517033 created "2016-06-24" @default.
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- W2364517033 date "2010-01-01" @default.
- W2364517033 modified "2023-09-25" @default.
- W2364517033 title "Effects of Polydatin on Production of Nitric Oxide in Pulmonary Endothelial Cells" @default.
- W2364517033 hasPublicationYear "2010" @default.
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