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- W2364524243 abstract "Objective:To explore the effect of verapamil on the activition of α1(Ⅰ) collagen gene promotor induced by TGF β1. Methods: The recombinant pCOLH 1.5 and pCOLH2.5 of α1(Ⅰ) collagen gene promotor were transfected to rat mesangial cell and were treated with different concentration of TGF β1 and verapamil. The activity of CAT were measured by ELISA method. Results:TGF β1 enhanced the activity of pCOLH1.5 and pCOLH2.5(1.498 and 1.551 fold,respectively) significantly compared to the control; Verapamil inhibited the activity of the 2 recombinants. The activity of CAT stimulated by verapamil + TGF β1 was remarkably decreased compared with the activity of pCOLH2.5 promotor by TGF β1. Conclusion:Verapamil can not only inhibit the activity of gene promotor derectly, but also partly block the activity of α1(Ⅰ) collagen gene promotor induced by TGF β1." @default.
- W2364524243 created "2016-06-24" @default.
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- W2364524243 date "2002-01-01" @default.
- W2364524243 modified "2023-09-25" @default.
- W2364524243 title "Verapamil blocking activition of α1(I) collagen gene promotor induced by TGF-β1" @default.
- W2364524243 hasPublicationYear "2002" @default.
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