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- W2364529224 abstract "Objective In order to study the amounts of the hepatitis C viral RNA in the serum associated with that in the liver tissue.Methods The concentrations of HCV RNA were detected in 24 patients with chronic hepatitis C by quantitative polymerase chain reaction which was based on a Amplisensor assay. Results The amounts of HCV RNA (10 5 to 10 9.2 copies/ml) in the serum correlated with that in the liver tissue (10 8 to 10 12 copies/g) ( P 0.01). One gram of the infected liver tissue contained 10 2 to 10 4 times as many copies of the viral RNA as that of 1ml serum. Liver tissue of chronic aggressive hepatitis contained significantly higher amounts of the viral RNA than those of chronic persistent hepatitis. There was a positive correlation between the titer of HCV RNA in the serum and ALT level. Conclusion These results suggested that a significant correlation between the quantity of HCV RNA in the liver and histological acti vity of chronic hepatitis C, and the serum HCV RNA levels could be considered as a marker for monitoring intrahepatic viral RNA." @default.
- W2364529224 created "2016-06-24" @default.
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- W2364529224 date "1999-01-01" @default.
- W2364529224 modified "2023-09-26" @default.
- W2364529224 title "Study on the relationship of HCV RNA between serum and liver tissue of hepatitis C" @default.
- W2364529224 hasPublicationYear "1999" @default.
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