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- W2364536545 abstract "Objective To assess the characteristics of the stable chronic cor pulmonale(HACCP)patients complicated by obstructive sleep apnea-hyponea syndrome(OSAHS)and therapy effect of NIPPV at high altitude area.Methods There were 40 stable simple HACCP inpatients(A group)and 32 stable HACCP inpatients complicated by OSAHS(B group).The ata in comparisons between the groups were as follows:apnea-hypopnea index(AHI),sleep mean oxyhemoglobin saturation(MsaO2),mean minimum SaO2(MmSaO2),forced expiratory volume in 1 second(FEV1)as expressed percent predicted(FEV1%),FEV1 to forced vital capacity(FEV1/FVC),arterial oxygen partial pressure(PaO2),arterial carbon dioxide partial pressure(PaCO2),mean pulmonary arterial pressure(mPAP)and outflow tract of right ventricle(RVOT).The B group were treated with nocturnal noninvasive positive pressure ventilation(NIPPV),FEV1%,FEV1/FVC,PaO2,PaCO2,mPAP,RVOT were measured after 3 weeks treatment.Results FEV1%,FEV1/FVC,PaO2,MSaO2 and MmSaO2 in the group B[(35.2±4.4)%,(42.5±5.4)%,(39.7±4.7)mmHg,(64.0±5.7)%,(51.3±6.1)%]were significantly lower than those in the group A[(44.1±5.6)%,(50.3±6.7)%,(48.2±5.5)mmHg,(73.6±6.2)%,(65.5±6.0)% all P0.01].The measures of PaCO2,mPAP,RVOT,AHI[(55.9±7.1)mmHg,(46.2±5.5)mmHg,(40.2±4.2)mm,(46.2±11.2)time/hour] were significantly higher in the group B than those in the group A[(46.7±5.4)mmHg,(34.4±4.2)mmHg,(34.1±3.5)mm,(4.5±0.9)time/hour,all P0.01)].In the group B,AHI was negatively correlated with FEV1%,FEV1/FVC,PaO2,MsaO2,MmSaO2(r=-0.621,-0.633,-0.754,-0.724,-0.719,respectively,all P0.01)positive correlated with PaCO2,mPAP,RVOT(r=0.622,0.848,0.784,respectively,all P0.01).After 3 weeks of treatment,FEV1%,FEV1/FVC,PaO2[(39.0±5.8)%,(46.7±6.8)%,(45.2±5.1)mmHg] significantly increased(P0.01 or P0.05)and PaCO2,mPAP RTOV[(48.3±6.7)mmHg,(38.4±5.7)mmHg,(33.5±3.8)mm]significantly decreased(all P0.01)in the group B compared that the before treatment.Conclusion Damage of heart and lung function in HACCP patients complicated by OSAHS is serious.The more AHI,the more serious of heart and lung function damage.NIPPV can significantly improve damage of heart and lung function in HACCP patients complicated by OSAHS." @default.
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- W2364536545 date "2010-01-01" @default.
- W2364536545 modified "2023-09-23" @default.
- W2364536545 title "Characteristics of the stable chronic cor pulmonale patients complicated by obstructive sleep apnea-hyponea syndrome and therapy effect of NIPPV at high altitude area" @default.
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