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- W2364541330 abstract "Objective To explore the feasibility of using a nonreactive,permanent endoskeletal scaffold to create the hypothesis with special shape which covered with tissue-engineered cartilage.Methods Porcine BMSCs and articular chondrocytes were isolated and expanded respectively in vitro and then mixed at the ratio of 7:3(BMSCs:Chondrocytes).The mixed cells in the concentration of 10×107/ml were seeded onto the PGA(polyglycolic acid) which wrapped the nonreactive,permanent endoskeletal scaffoldhigh-density polyethylene(HDPE) as the experimental group.BMSCs and chondrocytes of the same concentration were seeded respectively onto the scaffold as the negative control group and the positive control group.After cultured in vitro for two weeks,the cell-scaffolds construct were implanted into subcutaneous pockets on the back of nude mice.Four and eight weeks later,the formed cartilage prosthesis were harvested and then evaluated by gross view,histology,and immunohistochemistry.Results Cells in all groups had fine adhesion to the scaffold and could secrete extracellular matrix.All specimens in experimental groups and positive control group formed mature cartilage with collagen Ⅱ expression.The mature cartilage wrapped HDPE compactly and grown into the gap of HDPE.Mature lacuna structures and metachromatic matrices were also observed in these specimens.In contrast,specimens in negative control group showed mainly fibrous tissue.Conclusion This pilot technique combining tissue engineering with a permanent biocompatible endoskeleton demonstrated the feasibility of creating special shaped prosthesis covered with tissue-engineered cartilage." @default.
- W2364541330 created "2016-06-24" @default.
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- W2364541330 date "2007-01-01" @default.
- W2364541330 modified "2023-09-23" @default.
- W2364541330 title "Preliminary study of constructing tissue-engineered cartilage with the endoskeletal scaffold of HDPE by co-culture of bone marrow stromal cells and chondrocytes" @default.
- W2364541330 hasPublicationYear "2007" @default.
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