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- W2364547674 abstract "AIM:To investigate the protective effect of direct electrotransfer of hHGF gene against renal ischemia-reperfusion injury.METHODS:Male SD rats(n=20)were randomly divided into study group and control group,10 in each group.The plasmid of hHGF gene was transferred into the kidney of the rats in study group with electrotransfer technique 3 d before renal warm ischemia.The pharmacokinetics of hHGF and the function and histological change of the kidney after ischemia-reperfusion injury were determined.RESULTS:The expression of hHGF gene in the renal tissue and the plasma of the animals in study group was significantly higher than those in controls(P0.01).The serum creatinine level in study group was significantly lower than controls(P0.01)and the rats in study group had faster recovery of renal function when compared to controls.It was shown by histological evaluation that there were less apoptosis scores of tubular cells and less lymphocyte,macrophage and neutrophil infiltration in study group as compared to controls(P0.05).CONCLUSION:The direct kidney electrotransfer of hHGF gene into the kidney is effective in preventing renal ischemia-reperfusion injury in rats." @default.
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- W2364547674 date "2007-01-01" @default.
- W2364547674 modified "2023-09-23" @default.
- W2364547674 title "Protective effect of hHGF gene electrotransfer against renal ischemia-reperfusion injury in rats" @default.
- W2364547674 hasPublicationYear "2007" @default.
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