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- W2364573751 abstract "Objective To investigate the curative effect of triptorelin on BA and PAH of idiopathic central precocious puberty girls. Methods 86 cases of central precocious puberty girls admitted to our hospital from February 2011 to November 2013 were treated with triptorelin. Initial dose was 80 ~ 110 μg / kg,strengthening treatment once after 15 days' treatment,then treated once every month. After 3 months of treatment,according to the situation of gonadal axis suppression,to make the dose reduce to 60 ~ 100 μg / kg every month,maintenance therapy,treated for 1 ~ 3 years. The bone age( BA),predicted adult height( PAH) were observed before and after 6,12,24,36 months treatment. Results After treatment,the increase of BA was less than that of age. In children aged(9. 32 ± 1. 11),(9. 86 ± 1. 16),(1 0. 45 ±1. 10) and(11. 07 ± 1. 15) years,before treatment BA was(10. 65 ± 1. 03) years old,significantly lower than those of 6,12,24 and 36 months treatment [( 11. 02 ± 0. 97),( 11. 45 ± 1. 02),( 11. 77 ± 1. 14) and( 11. 99 ± 1. 06) years old,respectively,all P 0. 01]. Before treatment,ΔBA / ΔCA ratio was(1. 72 ± 0. 26),significantly higher than those of 6,12,24 and 36 months treatment(0. 84 ± 0. 36,0. 59 ± 0. 29,0. 45 ± 0. 31,0. 23 ± 0. 28 and 0. 23 ± 0. 28,respectively;all P 0. 01). Before treatment,PAH was(151. 22 ± 4. 65) cm,obviously lower than those of 6,12, 24 and 36 months treatment [(152. 28 ± 3. 90),(153. 15 ± 4. 34),(154. 56 ± 5. 07) and(156. 32 ± 5. 31) cm,respectively;all P 0. 01]. Conclusion Triptorelin can effectively inhibit the development of sexual characteristics and increase of bone age and improve adult height in children with idiopathic central precocious puberty." @default.
- W2364573751 created "2016-06-24" @default.
- W2364573751 creator A5081346706 @default.
- W2364573751 date "2014-01-01" @default.
- W2364573751 modified "2023-09-26" @default.
- W2364573751 title "Effect of triptorelin on bone age and predicted adult height of central precocious puberty girls" @default.
- W2364573751 hasPublicationYear "2014" @default.
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