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- W2364578196 abstract "Objective To observe the effect of Kangxin capsule on nerve growth factor (NGF) expression in cortical parietal lobe and hippocampus CA1 zone and quantity and structure of synapse of vascular dementia (VD) model rats. Methods The experimental VD rats, made by photochemically initiated thrombosis, were divided into six groups: model group, control group, high dosage group, middle dosage group, low dosage group and western medicine group. Then structure of synapse in the cortical parietal lobe and hippocampus CA1 zone of rats in every group was observed by electron microscope, synapse number density was calculated, and the NGF positive cells in cortical parietal lobe and hippocampus CA1 zone were observed with immunohistochemical quantitative analysis. Results Under electron microscope, each group treated with Kangxin capsule and western medicine group demonstrated a normal quantity and complete structure of synapse, was similar to that in control group, better than that in model group; and NGF positive cells in the cortical parietal lobe and hippocampus CA1 zone were significantly more than that of model group (P0.01), similar to that of control group. Conclusions Kangxin capsule can induce the NGF expression in cortical parietal lobe and hippocampus CA1 zone of VD model rats, protect structure and quantity of synapse and promote neuroprotective effect after cerebral ischemia." @default.
- W2364578196 created "2016-06-24" @default.
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- W2364578196 date "2005-01-01" @default.
- W2364578196 modified "2023-09-25" @default.
- W2364578196 title "The effect of Kangxin capsule on nerve growth factor expression in the cortical parietal lobe and hippocampus CA1 zone of vascular dementia model rats" @default.
- W2364578196 hasPublicationYear "2005" @default.
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