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- W2364594577 abstract "Objective To investigate the clinical value of soluble triggering receptor Expressed on Myeloid Cell-1(sTREM-1) in ventilator-associated pneumonia and to provide experimental research principle for early clinical diagnosis of VAP.Methods Patients were divided into four groups.In the ICU,25 patients with suspected ventilator-associated pneumonia(VAP) were selected,14 cases of them being confirmed as VAP diagnosed group(Group A),the other 11 cases as mechanical ventilation control group(Group B) according to the results of bacterial cultures.The other two control groups included 28 cases,10 patients with pulmonary fibrosis(Group C) and 18 healthy cases(Group D).Every case was given the protective lung lavage guided by fiberoptic bronchoscope when they were selected and collected fluid samples and corresponding serum samples.ELASA method was used to measured titre of sTREM-1 in BALF and serum of experimental group and control groups.WBC,ESR and CRP in serum were measured and the clinical pulmonary infection scores(CPIS) were recorded in group A and group B.Results ①sTREM-1 titre in BALF of group A increased significantly compared with those of group B,group C or group D(all P0.05).sTREM-1 titre in serum of group A compared with those of group B or group D was no significant difference(all P0.05).②The areas under receiver operating characteristic(ROC) curve of sTREM-1 and other factors in BALF of group A were measured.The results suggested that sTREM-1 was the strongest indicator of VAP.While taken a cut-off value of 143.83 ng/L,its diagnostic sensitivity was 92.9% and specificity was 81.8%.Conclusion sTREM-1 assay in BALF may be regarded as a better marker in both the early diagnosis of VAP and the reliable differentiation from non-infectious pulmonary infiltrates in ventilated patients." @default.
- W2364594577 created "2016-06-24" @default.
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- W2364594577 date "2012-01-01" @default.
- W2364594577 modified "2023-09-28" @default.
- W2364594577 title "Role of Soluble Triggering Receptor Expressed on Myeloid Cell-1 in the Bronchoalveolar Lavage Fluid in the Diagnosis of Ventilator-Associated Pneumonia" @default.
- W2364594577 hasPublicationYear "2012" @default.
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