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- W2364597179 abstract "OBJECTIVE A method was established to study the pharmacokinetics of Pseudoephedrine tablet by LC-MS.METHODS 10 healthy volunteers received tested tablets for a single oral dose of Pseudoephedrine 120,240 mg and multidose.Drug concentrations in plasma were determined.RESULTS Pharmacokinetic parameters of Pseudoephedrine after single oral doses(120、240 mg)were as follow:T1/2β:(5.5±0.7)h、(5.2±0.7)h;tmax:(4.8±0.9)h、(4.7±0.8)h;Cmax:(226.7±21.1)μg·L-1、(455.1±100.2)μg·L-1;CL:(41.0±18.6)、(43.9±15)L·h-1;V/F:(209.3±116.0)、(218.4±103.5)L;AUC(0-t):(2 929.9±474.9)、(5 466.8±1 372.6)μg·h·L-1;MRT(0-t):(10.2±0.7)h、(9.6±0.8)h.The main pharmacokinetic parameters of multidose(120 mg,bid)were as follows:Cssmax:(272.0±52.6)μg·L-1,Cssmin:(105.0±37.2)μg·L-1,Cav:(198.6±39.0)μg·L-1,CL(50.4±16.8)L·h-1,DF:(0.86±0.20),AUCss:(2 382.6±467.4)μg·h·L-1.CONCLUSION The method was sensitive,the results were accurate,a one-compartment open pharmacokinetic model was adapted to Pseudoephedrine plasma concentration-time data analysis,the main pharmacokinetic parameters were similar to those reported domestic and abroad.so it could provide information in clinic." @default.
- W2364597179 created "2016-06-24" @default.
- W2364597179 creator A5024754592 @default.
- W2364597179 date "2007-01-01" @default.
- W2364597179 modified "2023-09-23" @default.
- W2364597179 title "Pharmacodynamic study of pseudoephedrine compound sustained-release tablets" @default.
- W2364597179 hasPublicationYear "2007" @default.
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