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- W2364599175 abstract "The folate receptor is a useful target that has been exploited for tumor-specific drug delivery.In this study,human serum albumin-folate conjugate(HSA-FA) was prepared with HSA as the linker and drug carrier.Coupling degree of the conjugate show that one molecule of HSA is loaded with about three folic acid molecules.The corresponding 99mTc-complex was successfully obtained by SnCl2 ·2H2O as reducing agent.The radiochemical purity of the product was above 90% by TLC and HPLC.The results of in vitro experiments show that the complex bound the KB tumor cells specifically.In vivo study of 99mTc-HSA-FA was performed in Kunming mice bearing S180 tumor.Compared with 99mTc-HSA,the biodistribution of 99mTc-HSA-FA was different and the tumor uptake was significantly increased(t = 12.03,P 0.05).99mTc-HSA-FA showed a high accumulation[(4.37 ± 1.12) % ID/g at 1h]and good retention[(3.40 ± 0.69) % ID/g at 4 h]in tumor.The ratios of tumor/blood and tumor/muscle increased with time and were 0.45 and 4.28 at 1 h post injection,and reached 0.76 and 5.00 at 4 h post injection,respectively.After blocking with the cold ligand,the uptakes of kidney and tumor were lower than the control(t = 24.17 and 17.87,respectively,P 0.05).These results indicate the specific binding of HSA-FA to the folate receptor." @default.
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- W2364599175 date "2010-01-01" @default.
- W2364599175 modified "2023-09-25" @default.
- W2364599175 title "Preparation,Labeling and Biological Evaluation of Human Serum Albumin-folate Conjugate for Targeting Folate Receptor" @default.
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