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- W2364605846 abstract "Objective To evaluate the cerebralprotective effect of curcumin on neonatal rats with ischemic periventricular leukomalacia(PVL)in vitro.Methods The models of ischemic two-day-old neonatal rats were established by ligating bilateral common carotid arteries.The neonatal rats were divided into the sham group,hypoxic-ischemic(HI)group,pre-treat with curcumin before HI group and post-treat with curcumin after HI group.The neonatal rats were given curcumin at a dose of 50 mg/kg·d before or after ligating bilateral common carotid arteries.The assessment of cerebral pathology,the detection of the oxidation/anti-oxidation materials,and the analysis of the expression of Bcl-2/Bax and cleaved-Caspases-3、9 were undertaken in 48 hours after the surgery.Results The patho-logical changes in cerebral white matter were improved significantly in both of the curcumin groups compared to those in the HI group with 62.5% and 43.8% of severe pathological changes and 12.5% of normal white matters,respectively.The IOD(integrated optical density)values of O4(oligodendrocyte marker O4)and MBP(myelin basic protein) staining were increased,the activities of SOD(superoxide dismutases),GPx(glutathione peroxidase)and CAT(catalase)and level of GSH(glutathione)were increased,the level of MDA(malondialdehyde)was decreased,the expression of Bcl-2 was increased,the expression of Bax and the activation of caspase-3,9 were decreased significantly in both of curcumin groups compared to those in the HI group,respectively.Conclusions Curcumin exerts well protection on ischemia-induced white matter injury,and the effect may be related with its regulation on anti-oxidative defense system and the expression of apoptosis-associated proteins." @default.
- W2364605846 created "2016-06-24" @default.
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- W2364605846 date "2011-01-01" @default.
- W2364605846 modified "2023-09-26" @default.
- W2364605846 title "Cerebralprotective effect of curcumin on neonatal rats with ischemic periventricular leukomalacia" @default.
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