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• W2364609548 abstract "The anaphase-promoting complex (APC) is a multisubunit E3 ubiquitin ligase that controls cell cycle transition in proliferating cells. Recent studies show that Cdh1-APC is active in postmitotic neurons, which regulates axonal growth and patterning, synaptic development and neuronal survival. However, the role of Cdh1-APC in neural stem cells differentiation remains unknown. Using quantitative reverse transcription-PCR, we observed that Cdh1 was expressed higher in neurons than in neural stem cells in vitro. Cdh1 was upregulated, whereas Id2 (one downstream substrate of Cdh1-APC) was downregulated when primary neural stem cells were induced to differentiate into neurons by all-trans retinoic acid. This observation suggests that Cdh1 is involved in the control of neural stem cells differentiated into neurons." @default.
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• W2364609548 date "2010-01-06" @default.
• W2364609548 modified "2023-09-27" @default.
• W2364609548 title "Cdh1–APC is involved in the differentiation of neural stem cells into neurons" @default.
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• W2364609548 doi "https://doi.org/10.1097/wnr.0b013e32833312fe" @default.
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