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- W2364610007 abstract "Objective To investigate the effect of adenosine preconditioning on changes of energy metabolism and ultrastructure of myocardium. Methods Sixteen patients who underwent open heart surgery were randomly divided into adenosine group and control group with 8 cases in each group. Myocardial tissue was taken at three different time intervals: before cardiopulmonary bypass, 60 minutes after clamping the aorta and 30 minutes after declamping the aorta. The levels of ATP, and EC value were measured. The changes of myocardial ultrastructure were studied. Results The myocardial levels of ATP and EC in adnosine group were much higher than those in control group (P0 05). In adenosine group, electron microscopic findings of myocardial damage were less severe than those in control group. Conclusion Through mimicing preconditioning, adenosine can reduce the depletion of ATP, protect the structure and function of mitochondria. This may be one of the mechanisms of adenosine preconditioning." @default.
- W2364610007 created "2016-06-24" @default.
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- W2364610007 date "2001-01-01" @default.
- W2364610007 modified "2023-09-24" @default.
- W2364610007 title "Effect of adenosine preconditioning on changes of energy metabolism and ultrastructure of myocardium" @default.
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