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- W2364616173 abstract "Objective To establish a stable,homogeneous,well-tolerated and efficient protocol to induce rat cirrhosis models accompanied with ascites using an improved carbon tetrachloride(CCl4) combined with phenobarbital sodium and alcohol method,thus establishing a basis for serum albumin effectiveness evaluation test.Methods Ninety male Wistar rats were randomly divided into five groups: blank control group containing 10 rats,CCl4 group,CCl4 + phenobarbital sodium group,CCl4+alcohol group and CCl4+phenobarbital sodium+alcohol group containing 20 rats respectively as model groups.The control group was given normal drinking water and injected with olive oil intraperitoneally.Rats in model groups were given different drinking water and an intraperitoneal injection of CCl4 in a 2∶3 mixture with olive oil.The drugs given intraperitoneally were all at a dose of 2 ml/kg body mass,twice weekly for 12 weeks.We further measured the body mass and abdominal circumference,and tested the biochemical liver function indices as well as the colloid osmotic pressure(COP) to evaluate the different processes in these groups.At the end of the induced operation the randomly selected rats in each group were sacrificed,and a section of right liver lobe was obtained and examined by histopathological method.The statistical analysis data were performed.Results Cirrhosis accompanied with ascites developed in all model groups between 8 and 12 weeks.However,at the end of the eighth week,rats in CCl4+phenobarbital sodium+alcohol group were firstly detected to correspond with the model standards,CCl4+phenobarbital sodium group and CCl4+alcohol group were detected to have positive model signs at the ninth week.Only at the tenth week a few rats appeared to have ascites in CCl4 group.All the model groups showed significant differences in the biochemical liver function indices,COP and body mass than the rats in control group,and the most significant differences were observed in CCl4+phenobarbital sodium+alcohol group.The model rate in model groups was 65%,75%,75% and 80%,respectively.Histological examination showed that all the model groups developed liver cirrhosis with typical pseudolobule formation.Conclusion The use of carbon tetrachloride associated with phenobarbital sodium and alcohol presents an effective method to induce cirrhosis rat models with ascites,the model rate has a good advantage than other transitional methods." @default.
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- W2364616173 date "2012-01-01" @default.
- W2364616173 modified "2023-09-23" @default.
- W2364616173 title "Improvement and optimization of CCl_4 induced liver cirrhosis rats model accompanied with ascites" @default.
- W2364616173 hasPublicationYear "2012" @default.
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