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- W2364621154 abstract "Objective To investigate the age-related expression of 8-oxo-7,8-dihydroguanine (8-oxo-dG) in the mouse hippocampus of senescence-accelerated mice prone 8(SAMP8). Methods Randomly selected 1-, 4-, 8- and 12-month old SAMP8 and the age-matched control strain senescence-accelerated mice resistant 1 (SAMR1), with 6 mice in each group, immunohistochemistry analysis was used to explore the ways of change in the two strains of mice. Results 8-oxo-dG could be detected almost exclusively in the nuclei of neurons throughout the whole hippocampus of both strains at all tested age groups. No significant change was observed in CA1 and CA3 subregions among the four SAMR1 groups. Compared with the age-matched SAMR1 mice, no significant difference in 8-oxo-dG expression was observed in 1- and 4-month SAMP8 mice. However, significant increases of 8-oxo-dG in 8- and 12-month SAMP8 mice were observed, compared with the 1-month SMP8 group and with the age-matched SAMR1 groups. The pattern of change in CA3 was similar with that in CA1. Conclusions 8-oxo-dG in the hippocampus of SAMP8 mice increased markedly with the gaining of age." @default.
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- W2364621154 date "2009-01-01" @default.
- W2364621154 modified "2023-09-25" @default.
- W2364621154 title "The Age-related Increase of 8-oxo-7,8-dihydroguanine in the Hippocampus of Senescence-accelerated Mice Prone 8" @default.
- W2364621154 hasPublicationYear "2009" @default.
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